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Moderate to strong cytoplasmic and/or nuclear immunoreactivity was observed in malignant cells.
GENE INFORMATION
Gene name
MICU1 (HGNC Symbol)
Synonyms
CALC, CBARA1, EFHA3, FLJ12684
Description
Mitochondrial calcium uptake 1 (HGNC Symbol)
Entrez gene summary
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]
Q9BPX6 [Direct mapping] Calcium uptake protein 1, mitochondrial
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Transporters Accessory Factors Involved in Transport Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005758 [mitochondrial intermembrane space] GO:0006851 [mitochondrial calcium ion transport] GO:0006952 [defense response] GO:0032592 [integral component of mitochondrial membrane] GO:0034704 [calcium channel complex] GO:0036444 [calcium ion transmembrane import into mitochondrion] GO:0042802 [identical protein binding] GO:0046982 [protein heterodimerization activity] GO:0051260 [protein homooligomerization] GO:0051560 [mitochondrial calcium ion homeostasis] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0070509 [calcium ion import] GO:1990246 [uniplex complex]
Q9BPX6 [Direct mapping] Calcium uptake protein 1, mitochondrial
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005758 [mitochondrial intermembrane space] GO:0006851 [mitochondrial calcium ion transport] GO:0006952 [defense response] GO:0032592 [integral component of mitochondrial membrane] GO:0034704 [calcium channel complex] GO:0036444 [calcium ion transmembrane import into mitochondrion] GO:0042802 [identical protein binding] GO:0046982 [protein heterodimerization activity] GO:0051260 [protein homooligomerization] GO:0051560 [mitochondrial calcium ion homeostasis] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0070509 [calcium ion import] GO:1990246 [uniplex complex]
Q9BPX6 [Direct mapping] Calcium uptake protein 1, mitochondrial
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005758 [mitochondrial intermembrane space] GO:0006851 [mitochondrial calcium ion transport] GO:0006952 [defense response] GO:0032592 [integral component of mitochondrial membrane] GO:0034704 [calcium channel complex] GO:0036444 [calcium ion transmembrane import into mitochondrion] GO:0042802 [identical protein binding] GO:0046982 [protein heterodimerization activity] GO:0051260 [protein homooligomerization] GO:0051560 [mitochondrial calcium ion homeostasis] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0070509 [calcium ion import] GO:1990246 [uniplex complex]
