Tissue expression of BCCIP - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BCCIP
Gene description	BRCA2 and CDKN1A interacting protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	BCCIP (HGNC Symbol)
Synonyms	BCCIPalpha, TOK-1
Description	BRCA2 and CDKN1A interacting protein (HGNC Symbol)
Entrez gene summary	This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q26.2
Chromosome location (bp)	125823546 - 125853695
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107949 (version 83.38)
Entrez gene	56647
UniProt	Q9P287 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P287
Antibodypedia	BCCIP antibodies

PROTEIN BROWSER

BCCIP-001	BCCIP-002	BCCIP-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCCIP-001 ENSP00000357748 ENST00000368759	Q9P287 [Direct mapping] BRCA2 and CDKN1A-interacting protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0006974 [cellular response to DNA damage stimulus] GO:0007049 [cell cycle] GO:0019207 [kinase regulator activity] GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex] GO:0044822 [poly(A) RNA binding] GO:0061101 [neuroendocrine cell differentiation] Show all	322 aa 36.2 kDa	No	0
BCCIP-002 ENSP00000278100 ENST00000278100	Q9P287 [Direct mapping] BRCA2 and CDKN1A-interacting protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0007049 [cell cycle] GO:0019207 [kinase regulator activity] GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex] GO:0044822 [poly(A) RNA binding] GO:0061101 [neuroendocrine cell differentiation] Show all	314 aa 36 kDa	No	0
BCCIP-003 ENSP00000299130 ENST00000299130	Q9P287 [Direct mapping] BRCA2 and CDKN1A-interacting protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0007049 [cell cycle] GO:0019207 [kinase regulator activity] GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex] GO:0044822 [poly(A) RNA binding] GO:0061101 [neuroendocrine cell differentiation] Show all	292 aa 33.2 kDa	No	0