Expression of SLC2A9 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 2 (facilitated glucose transporter), member 9

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA066229

GENE INFORMATION
Gene name	SLC2A9 (HGNC Symbol)
Synonyms	Glut9, GLUTX, URATv1
Description	Solute carrier family 2 (facilitated glucose transporter), member 9 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p16.1
Chromosome location (bp)	9771153 - 10054936
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109667 (version 83.38)
Entrez gene	56606
UniProt	Q9NRM0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRM0
Antibodypedia	SLC2A9 antibodies

PROTEIN BROWSER

SLC2A9-001	SLC2A9-002	SLC2A9-006	SLC2A9-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC2A9-001 ENSP00000422209 ENST00000506583	Q9NRM0 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 9 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015758 [glucose transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	511 aa 55.7 kDa	No	>9
SLC2A9-002 ENSP00000264784 ENST00000264784	Q9NRM0 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 9 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015758 [glucose transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	540 aa 58.7 kDa	No	>9
SLC2A9-006 ENSP00000426800 ENST00000513129	D6REK5 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	198 aa 21.2 kDa	No	5
SLC2A9-201 ENSP00000311383 ENST00000309065	Q9NRM0 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 9 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015758 [glucose transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0046415 [urate metabolic process] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	511 aa 55.7 kDa	No	>9