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F-box and leucine-rich repeat protein 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Q9UKA2 [Direct mapping] F-box/LRR-repeat protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014)
Q9UKA2 [Direct mapping] F-box/LRR-repeat protein 4
Show all
MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
