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Most malignant cells exhibited moderate cytoplasmic positivity. Several renal and liver cancers were strongly stained. Several malignant gliomas, lymphomas and lung cancers were weakly stained or negative.
GENE INFORMATION
Gene name
B3GAT2 (HGNC Symbol)
Synonyms
GlcAT-S
Description
Beta-1,3-glucuronyltransferase 2 (HGNC Symbol)
Entrez gene summary
The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system. [provided by RefSeq, Jul 2008]
