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Most of the malignant cells showed weak to moderate cytoplasmic and/or nuclear immunoreactivity. A few cases of malignant melanomas, hepatocellular carcinomas and renal cancers were strongly stained. Several colorectal and endometrial cancers were negative.
Testis cancers showed moderate to strong nuclear staining while a few cases colorectal cancers displayed moderate cytoplasmic positivity. Malignant cells in general were weakly stained or negative.
A few cases of malignant melanomas, breast, prostate and endometrial cancers exhibited moderate cytoplasmic positivity with additional nuclear immunoreactivity in a fraction of cells. Other tumors were mainly negative.
GENE INFORMATION
Gene name
EYA4 (HGNC Symbol)
Synonyms
CMD1J, DFNA10
Description
EYA transcriptional coactivator and phosphatase 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
