Cell atlas - EYA4 - The Human Protein Atlas

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EYA4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	EYA4
Gene description	EYA transcriptional coactivator and phosphatase 4
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (HeLa, U-87 MG, RH-30, A549)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA004805
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HeLa, U-87 MG, RH-30, A549) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA004805	HeLa	Nucleoplasm
	HPA004805	RH-30	Nucleoplasm
	HPA004805	U-2 OS	Nucleoplasm	Intensity

GENE INFORMATION
Gene name	EYA4 (HGNC Symbol)
Synonyms	CMD1J, DFNA10
Description	EYA transcriptional coactivator and phosphatase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Chromosome	6
Cytoband	q23.2
Chromosome location (bp)	133240598 - 133532120
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112319 (version 83.38)
Entrez gene	2070
UniProt	O95677 (UniProt - Evidence at protein level)
neXtProt	NX_O95677
Antibodypedia	EYA4 antibodies

PROTEIN BROWSER

EYA4-001	EYA4-002	EYA4-006	EYA4-007	EYA4-008	EYA4-009	EYA4-011	EYA4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EYA4-001 ENSP00000356870 ENST00000367895	O95677 [Direct mapping] Eyes absent homolog 4 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0009653 [anatomical structure morphogenesis] GO:0016568 [chromatin modification] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0046872 [metal ion binding] Show all	639 aa 69.5 kDa	No	0
EYA4-002 ENSP00000433219 ENST00000525849	E9PLN6 [Direct mapping] Eyes absent homolog Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0007605 [sensory perception of sound] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0046872 [metal ion binding] Show all	616 aa 67 kDa	No	0
EYA4-006 ENSP00000395916 ENST00000452339	O95677 [Direct mapping] Eyes absent homolog 4 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0009653 [anatomical structure morphogenesis] GO:0016568 [chromatin modification] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0046872 [metal ion binding] Show all	585 aa 63.9 kDa	No	0
EYA4-007 ENSP00000388670 ENST00000430974	E7ESD5 [Direct mapping] Eyes absent homolog Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0007605 [sensory perception of sound] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0046872 [metal ion binding] Show all	570 aa 62 kDa	No	0
EYA4-008 ENSP00000347434 ENST00000355286	O95677 [Direct mapping] Eyes absent homolog 4 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0009653 [anatomical structure morphogenesis] GO:0016568 [chromatin modification] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0046872 [metal ion binding] Show all	616 aa 67.1 kDa	No	0
EYA4-009 ENSP00000432770 ENST00000531901	F2Z2Y1 [Direct mapping] Eyes absent homolog Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0007605 [sensory perception of sound] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0042474 [middle ear morphogenesis] GO:0046872 [metal ion binding] GO:0048839 [inner ear development] Show all	645 aa 70.1 kDa	No	0
EYA4-011 ENSP00000404558 ENST00000431403	O95677 [Direct mapping] Eyes absent homolog 4 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0009653 [anatomical structure morphogenesis] GO:0016568 [chromatin modification] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0046872 [metal ion binding] Show all	639 aa 69.4 kDa	No	0
EYA4-201 ENSP00000347294 ENST00000355167	O95677 [Direct mapping] Eyes absent homolog 4 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0007601 [visual perception] GO:0007605 [sensory perception of sound] GO:0009653 [anatomical structure morphogenesis] GO:0016568 [chromatin modification] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0046872 [metal ion binding] Show all	639 aa 69.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.