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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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THBS4
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Thrombospondin 4

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB004597

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A few cases of lung, pancreatic, liver cancer and malignant melanomas showed moderate cytoplasmic positivity. Remaining malignancies were weakly stained or negative.

GENE INFORMATION

Gene name

THBS4

Synonyms

Description

Thrombospondin 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Chromosome

5

Cytoband

q14.1

Chromosome location (bp)

79991311 - 80083287

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113296 (version 83.38)

Entrez gene

7060

UniProt

P35443 (UniProt - Evidence at protein level)

neXtProt

NX_P35443

Antibodypedia

THBS4 antibodies

PROTEIN BROWSER

THBS4-001
THBS4-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

THBS4-001
ENSP00000339730
ENST00000350881
P35443 [Direct mapping]
Thrombospondin-4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0006986 [response to unfolded protein]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0016525 [negative regulation of angiogenesis]
GO:0016529 [sarcoplasmic reticulum]
GO:0031012 [extracellular matrix]
GO:0031594 [neuromuscular junction]
GO:0034103 [regulation of tissue remodeling]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0043237 [laminin-1 binding]
GO:0048266 [behavioral response to pain]
GO:0048771 [tissue remodeling]
GO:0048812 [neuron projection morphogenesis]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051260 [protein homooligomerization]
GO:0051451 [myoblast migration]
GO:0051781 [positive regulation of cell division]
GO:0070062 [extracellular exosome]
GO:0071603 [endothelial cell-cell adhesion]
GO:0090023 [positive regulation of neutrophil chemotaxis]
Show all
961 aa
105.9 kDa
Yes 0
THBS4-005
ENSP00000422298
ENST00000511733
E7ES19 [Direct mapping]
Thrombospondin-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007155 [cell adhesion]
Show all
870 aa
96 kDa
No 0

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