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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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THBS4
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

THBS4

Gene description

Thrombospondin 4

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (smooth muscle, adipose tissue, heart muscle)
GTEx:Mixed
FANTOM5:Tissue enhanced (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression

Extracellular deposits and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Approved based on 1 antibody.
CAB004597
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (smooth muscle, adipose tissue, heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION

Gene name

THBS4

Synonyms

Description

Thrombospondin 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Chromosome

5

Cytoband

q14.1

Chromosome location (bp)

79991311 - 80083287

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113296 (version 83.38)

Entrez gene

7060

UniProt

P35443 (UniProt - Evidence at protein level)

neXtProt

NX_P35443

Antibodypedia

THBS4 antibodies

PROTEIN BROWSER

THBS4-001
THBS4-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

THBS4-001
ENSP00000339730
ENST00000350881
P35443 [Direct mapping]
Thrombospondin-4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0006986 [response to unfolded protein]
GO:0007155 [cell adhesion]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0016525 [negative regulation of angiogenesis]
GO:0016529 [sarcoplasmic reticulum]
GO:0031012 [extracellular matrix]
GO:0031594 [neuromuscular junction]
GO:0034103 [regulation of tissue remodeling]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0043237 [laminin-1 binding]
GO:0048266 [behavioral response to pain]
GO:0048771 [tissue remodeling]
GO:0048812 [neuron projection morphogenesis]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051260 [protein homooligomerization]
GO:0051451 [myoblast migration]
GO:0051781 [positive regulation of cell division]
GO:0070062 [extracellular exosome]
GO:0071603 [endothelial cell-cell adhesion]
GO:0090023 [positive regulation of neutrophil chemotaxis]
Show all
961 aa
105.9 kDa
Yes 0
THBS4-005
ENSP00000422298
ENST00000511733
E7ES19 [Direct mapping]
Thrombospondin-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007155 [cell adhesion]
Show all
870 aa
96 kDa
No 0

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