Expression of C9 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Complement component 9

Protein class

Disease related genes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029577	CAB002151

GENE INFORMATION
Gene name	C9
Synonyms
Description	Complement component 9 (HGNC Symbol)
Entrez gene summary	This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]
Chromosome	5
Cytoband	p13.1
Chromosome location (bp)	39284262 - 39424868
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113600 (version 83.38)
Entrez gene	735
UniProt	P02748 (UniProt - Evidence at protein level)
neXtProt	NX_P02748
Antibodypedia	C9 antibodies

PROTEIN BROWSER

C9-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C9-001 ENSP00000263408 ENST00000263408	P02748 [Direct mapping] Complement component C9 Complement component C9a Complement component C9b Show all	MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005579 [membrane attack complex] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006957 [complement activation, alternative pathway] GO:0006958 [complement activation, classical pathway] GO:0019836 [hemolysis by symbiont of host erythrocytes] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	559 aa 63.2 kDa	Yes	0