Cell atlas - C9 - The Human Protein Atlas

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C9

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	C9
Gene description	Complement component 9
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (U-698)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (uncertain)
Additional location	In addition localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA029577
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-698) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol.

Main location

Plasma membrane (uncertain)

Additional location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029577	A-431	Plasma membrane
	HPA029577	A-431	Cytosol
	HPA029577	U-2 OS	Plasma membrane
	HPA029577	U-2 OS	Cytosol
	HPA029577	U-251 MG	Plasma membrane
	HPA029577	U-251 MG	Cytosol

GENE INFORMATION
Gene name	C9
Synonyms
Description	Complement component 9 (HGNC Symbol)
Entrez gene summary	This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]
Chromosome	5
Cytoband	p13.1
Chromosome location (bp)	39284262 - 39424868
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113600 (version 83.38)
Entrez gene	735
UniProt	P02748 (UniProt - Evidence at protein level)
neXtProt	NX_P02748
Antibodypedia	C9 antibodies

PROTEIN BROWSER

C9-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C9-001 ENSP00000263408 ENST00000263408	P02748 [Direct mapping] Complement component C9 Complement component C9a Complement component C9b Show all	MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005579 [membrane attack complex] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006957 [complement activation, alternative pathway] GO:0006958 [complement activation, classical pathway] GO:0019836 [hemolysis by symbiont of host erythrocytes] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	559 aa 63.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.