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C9

GENERAL INFORMATION

Gene name

 C9

Gene description

 Complement component 9

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Distinct positivity in plasma.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 2 antibodies.
HPA029577 , CAB002151
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 C9

Synonyms

Description

 Complement component 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]

Chromosome

 5

Cytoband

 p13.1

Chromosome location (bp)

 39284262 - 39424868

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113600 (version 83.38)

Entrez gene

 735

UniProt

 P02748 (UniProt - Evidence at protein level)

neXtProt

 NX_P02748

Antibodypedia

 C9 antibodies

PROTEIN BROWSER
C9-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C9-001
ENSP00000263408
ENST00000263408
P02748 [Direct mapping]
Complement component C9 Complement component C9a Complement component C9b
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   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005579 [membrane attack complex]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006957 [complement activation, alternative pathway]
GO:0006958 [complement activation, classical pathway]
GO:0019836 [hemolysis by symbiont of host erythrocytes]
GO:0030449 [regulation of complement activation]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
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 559 aa
63.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.