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This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. The encoded protein also has a peptide that displays antimicrobial activity against C. albicans, E. coli, S. aureus, P. aeruginosa, and E. faecalis. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Nov 2014]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis] GO:0002576 [platelet degranulation] GO:0002839 [positive regulation of immune response to tumor cell] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006935 [chemotaxis] GO:0007162 [negative regulation of cell adhesion] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010468 [regulation of gene expression] GO:0010543 [regulation of platelet activation] GO:0010593 [negative regulation of lamellipodium assembly] GO:0010951 [negative regulation of endopeptidase activity] GO:0016525 [negative regulation of angiogenesis] GO:0019865 [immunoglobulin binding] GO:0020037 [heme binding] GO:0030168 [platelet activation] GO:0030193 [regulation of blood coagulation] GO:0030308 [negative regulation of cell growth] GO:0031093 [platelet alpha granule lumen] GO:0032956 [regulation of actin cytoskeleton organization] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0042730 [fibrinolysis] GO:0043065 [positive regulation of apoptotic process] GO:0043254 [regulation of protein complex assembly] GO:0043395 [heparan sulfate proteoglycan binding] GO:0043537 [negative regulation of blood vessel endothelial cell migration] GO:0046872 [metal ion binding] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050832 [defense response to fungus] GO:0051894 [positive regulation of focal adhesion assembly] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway] GO:2000504 [positive regulation of blood vessel remodeling] GO:2001027 [negative regulation of endothelial cell chemotaxis]