We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancer tissues displayed moderate to strong staining. Breast, testicular, gastric, skin and prostate cancers as well as lymphomas and melanomas were weakly stained or negative in a majority of cases.
Cancer tissues showed weak to moderate cytoplasmic and nuclear immunoreactivity. Most cases of lymphomas, melanomas, skin and testicular cancers were negative.
Moderate cytoplasmic and occasional nuclear positivity was seen in most renal, hepatocellular carcinomas, pancreatic, endometrial, few ovarian and cervical cancers. All other cancers were weakly stained or negative.
GENE INFORMATION
Gene name
TP53I3 (HGNC Symbol)
Synonyms
PIG3
Description
Tumor protein p53 inducible protein 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
