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Cancer tissues showed moderate to strong cytoplasmic positivity, and a few cases with additional membranous positivity. Several lymphomas, renal cancers and hepatocellular carcinomas were weakly stained or negative.
Most cancer cells showed weak to moderate cytoplasmic and membranous immunoreactivity. A few cases of melanomas and gliomas were strongly stained. Most cases of lymphomas and endometrial cancers were negative.
GENE INFORMATION
Gene name
EHBP1 (HGNC Symbol)
Synonyms
KIAA0903, NACSIN
Description
EH domain binding protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]