Cell atlas - LHX4 - The Human Protein Atlas

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LHX4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	LHX4
Gene description	LIM homeobox 4
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Cell line enhanced (BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055705
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055705	A549	Nuclear speckles
	HPA055705	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	LHX4 (HGNC Symbol)
Synonyms	Gsh4
Description	LIM homeobox 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]
Chromosome	1
Cytoband	q25.2
Chromosome location (bp)	180230286 - 180278982
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121454 (version 83.38)
Entrez gene	89884
UniProt	Q969G2 (UniProt - Evidence at protein level)
neXtProt	NX_Q969G2
Antibodypedia	LHX4 antibodies

PROTEIN BROWSER

LHX4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LHX4-001 ENSP00000263726 ENST00000263726	Q969G2 [Direct mapping] LIM/homeobox protein Lhx4 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0001890 [placenta development] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008045 [motor neuron axon guidance] GO:0008270 [zinc ion binding] GO:0009887 [organ morphogenesis] GO:0021526 [medial motor column neuron differentiation] GO:0043066 [negative regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] Show all	390 aa 43.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.