Cell atlas - FAM126A - The Human Protein Atlas

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FAM126A

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	FAM126A
Gene description	Family with sequence similarity 126, member A
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA042873
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042873	A-431	Plasma membrane
	HPA042873	A-431	Cytosol
	HPA042873	U-2 OS	Plasma membrane
	HPA042873	U-2 OS	Cytosol
	HPA042873	U-251 MG	Cytosol

GENE INFORMATION
Gene name	FAM126A (HGNC Symbol)
Synonyms	DRCTNNB1A , HCC, HYCC1, hyccin
Description	Family with sequence similarity 126, member A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene may play a part in the beta-catenin/Lef signaling pathway. Expression of this gene is down-regulated by beta-catenin. Defects in this gene are a cause of hypomyelination with congenital cataract (HCC). [provided by RefSeq, Oct 2008]
Chromosome	7
Cytoband	p15.3
Chromosome location (bp)	22889371 - 23014130
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122591 (version 83.38)
Entrez gene	84668
UniProt	Q9BYI3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYI3
Antibodypedia	FAM126A antibodies

PROTEIN BROWSER

FAM126A-001	FAM126A-002	FAM126A-006	FAM126A-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM126A-001 ENSP00000403396 ENST00000432176	Q9BYI3 [Direct mapping] Hyccin A0A024RA06 [Target identity:100%; Query identity:100%] Down-regulated by Ctnnb1, a, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0008150 [biological_process] Show all	521 aa 57.6 kDa	No	0
FAM126A-002 ENSP00000397168 ENST00000440481	H7C0W7 [Direct mapping] Hyccin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		471 aa 52 kDa	No	0
FAM126A-006 ENSP00000386246 ENST00000409923	B8ZZJ1 [Direct mapping] Hyccin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		419 aa 46.9 kDa	No	0
FAM126A-008 ENSP00000386624 ENST00000409763	B8ZZA2 [Direct mapping] Hyccin Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 13 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.