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Most testicular cancers and a majority of renal cancers showed moderate cytoplasmic staining. Remaining cancer cells were weakly stained or negative.
GENE INFORMATION
Gene name
INHBA
Synonyms
Description
Inhibin, beta A (HGNC Symbol)
Entrez gene summary
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq, Jul 2008]
P08476 [Direct mapping] Inhibin beta A chain A4D1W7 [Target identity:100%; Query identity:100%] Inhibin, beta A (Activin A, activin AB alpha polypeptide); Inhibin, beta A (Activin A, activin AB alpha polypeptide), isoform CRA_a; cDNA FLJ75379, highly similar to Homo sapiens inhibin, beta A (activin A, activin AB alpha polypeptide), mRNA
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0001541 [ovarian follicle development] GO:0001707 [mesoderm formation] GO:0001942 [hair follicle development] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005623 [cell] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006952 [defense response] GO:0007050 [cell cycle arrest] GO:0007166 [cell surface receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007399 [nervous system development] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0008584 [male gonad development] GO:0010628 [positive regulation of gene expression] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0017046 [peptide hormone binding] GO:0021773 [striatal medium spiny neuron differentiation] GO:0030154 [cell differentiation] GO:0030218 [erythrocyte differentiation] GO:0030308 [negative regulation of cell growth] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032924 [activin receptor signaling pathway] GO:0034711 [inhibin binding] GO:0035987 [endodermal cell differentiation] GO:0040007 [growth] GO:0042326 [negative regulation of phosphorylation] GO:0042476 [odontogenesis] GO:0042493 [response to drug] GO:0042541 [hemoglobin biosynthetic process] GO:0042701 [progesterone secretion] GO:0042802 [identical protein binding] GO:0043408 [regulation of MAPK cascade] GO:0043509 [activin A complex] GO:0043512 [inhibin A complex] GO:0045077 [negative regulation of interferon-gamma biosynthetic process] GO:0045578 [negative regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045650 [negative regulation of macrophage differentiation] GO:0045786 [negative regulation of cell cycle] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046880 [regulation of follicle-stimulating hormone secretion] GO:0046881 [positive regulation of follicle-stimulating hormone secretion] GO:0046882 [negative regulation of follicle-stimulating hormone secretion] GO:0046982 [protein heterodimerization activity] GO:0048333 [mesodermal cell differentiation] GO:0048468 [cell development] GO:0048471 [perinuclear region of cytoplasm] GO:0060021 [palate development] GO:0060279 [positive regulation of ovulation] GO:0060395 [SMAD protein signal transduction] GO:0061029 [eyelid development in camera-type eye] GO:0070699 [type II activin receptor binding] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071397 [cellular response to cholesterol] GO:0097154 [GABAergic neuron differentiation] GO:0097191 [extrinsic apoptotic signaling pathway] GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
P08476 [Direct mapping] Inhibin beta A chain A4D1W7 [Target identity:100%; Query identity:100%] Inhibin, beta A (Activin A, activin AB alpha polypeptide); Inhibin, beta A (Activin A, activin AB alpha polypeptide), isoform CRA_a; cDNA FLJ75379, highly similar to Homo sapiens inhibin, beta A (activin A, activin AB alpha polypeptide), mRNA
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle] GO:0001541 [ovarian follicle development] GO:0001942 [hair follicle development] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005623 [cell] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006952 [defense response] GO:0007050 [cell cycle arrest] GO:0007166 [cell surface receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007399 [nervous system development] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0008584 [male gonad development] GO:0010628 [positive regulation of gene expression] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0017046 [peptide hormone binding] GO:0021773 [striatal medium spiny neuron differentiation] GO:0030154 [cell differentiation] GO:0030218 [erythrocyte differentiation] GO:0030308 [negative regulation of cell growth] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032924 [activin receptor signaling pathway] GO:0035987 [endodermal cell differentiation] GO:0040007 [growth] GO:0042326 [negative regulation of phosphorylation] GO:0042476 [odontogenesis] GO:0042493 [response to drug] GO:0042541 [hemoglobin biosynthetic process] GO:0042701 [progesterone secretion] GO:0042802 [identical protein binding] GO:0043408 [regulation of MAPK cascade] GO:0043509 [activin A complex] GO:0043512 [inhibin A complex] GO:0045077 [negative regulation of interferon-gamma biosynthetic process] GO:0045578 [negative regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045650 [negative regulation of macrophage differentiation] GO:0045786 [negative regulation of cell cycle] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046880 [regulation of follicle-stimulating hormone secretion] GO:0046881 [positive regulation of follicle-stimulating hormone secretion] GO:0046882 [negative regulation of follicle-stimulating hormone secretion] GO:0048468 [cell development] GO:0060021 [palate development] GO:0060279 [positive regulation of ovulation] GO:0060395 [SMAD protein signal transduction] GO:0061029 [eyelid development in camera-type eye] GO:0070699 [type II activin receptor binding] GO:0097154 [GABAergic neuron differentiation] GO:0097191 [extrinsic apoptotic signaling pathway] GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]