Expression of HOXC11 in cancer - Summary

CANCER ATLAS

Gene description

Homeobox C11

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA038291

GENE INFORMATION
Gene name	HOXC11 (HGNC Symbol)
Synonyms	HOX3H
Description	Homeobox C11 (HGNC Symbol)
Entrez gene summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	53973126 - 53977643
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123388 (version 83.38)
Entrez gene	3227
UniProt	O43248 (UniProt - Evidence at protein level)
neXtProt	NX_O43248
Antibodypedia	HOXC11 antibodies

PROTEIN BROWSER

HOXC11-001	HOXC11-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOXC11-001 ENSP00000446680 ENST00000546378	O43248 [Direct mapping] Homeobox protein Hox-C11 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001501 [skeletal system development] GO:0001656 [metanephros development] GO:0001759 [organ induction] GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007492 [endoderm development] GO:0009952 [anterior/posterior pattern specification] GO:0009954 [proximal/distal pattern formation] GO:0042733 [embryonic digit morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060272 [embryonic skeletal joint morphogenesis] Show all	304 aa 33.7 kDa	No	0
HOXC11-002 ENSP00000243082 ENST00000243082	J3KMZ0 [Direct mapping] Homeobox protein Hox-C11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	378 aa 40.5 kDa	No	1