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Several cases of ovarian, cervical, lung and urothelial cancers along with a single case of carcinoid and Hodgkins lymphoma showed moderate to strong nuclear positivity. Prostate cancers and several breast, testicular and skin cancers exhibited weak to moderate staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
SIX1 (HGNC Symbol)
Synonyms
DFNA23
Description
SIX homeobox 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008]