Expression of FLNC in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Filamin C, gamma

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006135

GENE INFORMATION
Gene name	FLNC (HGNC Symbol)
Synonyms	ABP-280, ABPL, FLN2
Description	Filamin C, gamma (HGNC Symbol)
Entrez gene summary	This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q32.1
Chromosome location (bp)	128830377 - 128859274
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128591 (version 83.38)
Entrez gene	2318
UniProt	Q14315 (UniProt - Evidence at protein level)
neXtProt	NX_Q14315
Antibodypedia	FLNC antibodies

PROTEIN BROWSER

FLNC-001	FLNC-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FLNC-001 ENSP00000327145 ENST00000325888	Q14315 [Direct mapping] Filamin-C Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008092 [cytoskeletal protein binding] GO:0016528 [sarcoplasm] GO:0030018 [Z disc] GO:0030506 [ankyrin binding] GO:0034329 [cell junction assembly] GO:0042383 [sarcolemma] GO:0043034 [costamere] GO:0048747 [muscle fiber development] Show all	2725 aa 291 kDa	No	0
FLNC-002 ENSP00000344002 ENST00000346177	Q14315 [Direct mapping] Filamin-C Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008092 [cytoskeletal protein binding] GO:0030018 [Z disc] GO:0030506 [ankyrin binding] GO:0034329 [cell junction assembly] GO:0042383 [sarcolemma] GO:0043034 [costamere] Show all	2692 aa 287.3 kDa	No	0