Fields »
ABOUT
HELP
BLOG
MBD4

GENERAL INFORMATION

Gene name

 MBD4

Gene description

 Methyl-CpG binding domain 4 DNA glycosylase

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA002031
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MBD4 (HGNC Symbol)

Synonyms

 MED1

Description

 Methyl-CpG binding domain 4 DNA glycosylase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

Chromosome

 3

Cytoband

 q21.3

Chromosome location (bp)

 129430944 - 129440179

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129071 (version 83.38)

Entrez gene

 8930

UniProt

 O95243 (UniProt - Evidence at protein level)

neXtProt

 NX_O95243

Antibodypedia

 MBD4 antibodies

PROTEIN BROWSER
MBD4-001
MBD4-002
MBD4-003
MBD4-009
MBD4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MBD4-001
ENSP00000249910
ENST00000249910
O95243 [Direct mapping]
Methyl-CpG-binding domain protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0003696 [satellite DNA binding]
GO:0003824 [catalytic activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0008263 [pyrimidine-specific mismatch base pair DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0032355 [response to estradiol]
GO:0045008 [depyrimidination]
Show all
 580 aa
66.1 kDa 		No 0
MBD4-002
ENSP00000424873
ENST00000503197
O95243 [Direct mapping]
Methyl-CpG-binding domain protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0003696 [satellite DNA binding]
GO:0003824 [catalytic activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0008263 [pyrimidine-specific mismatch base pair DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0045008 [depyrimidination]
Show all
 540 aa
60.9 kDa 		No 0
MBD4-003
ENSP00000394080
ENST00000429544
O95243 [Direct mapping]
Methyl-CpG-binding domain protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0003696 [satellite DNA binding]
GO:0003824 [catalytic activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0008263 [pyrimidine-specific mismatch base pair DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0045008 [depyrimidination]
Show all
 574 aa
65.3 kDa 		No 0
MBD4-009
ENSP00000422327
ENST00000507208
O95243 [Direct mapping]
Methyl-CpG-binding domain protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0003696 [satellite DNA binding]
GO:0003824 [catalytic activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0008263 [pyrimidine-specific mismatch base pair DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0045008 [depyrimidination]
Show all
 572 aa
64.8 kDa 		No 0
MBD4-201
ENSP00000376959
ENST00000393278
O95243 [Direct mapping]
Methyl-CpG-binding domain protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003696 [satellite DNA binding]
GO:0003824 [catalytic activity]
GO:0004520 [endodeoxyribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0008263 [pyrimidine-specific mismatch base pair DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0045008 [depyrimidination]
Show all
 262 aa
30.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.