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Most cancer tissues showed weak to moderate nuclear and/or cytoplasmic positivity.
GENE INFORMATION
Gene name
TERF2 (HGNC Symbol)
Synonyms
TRBF2, TRF2
Description
Telomeric repeat binding factor 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]