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FLNB

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GENERAL INFORMATION

Gene name

 FLNB

Gene description

 Filamin B, beta

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane. In addition localized to the cytosol, the Golgi apparatus & actin filaments.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

Additional location

 In addition localized to the Golgi apparatus (approved), Actin filaments (approved), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA004747 , CAB019322
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane. In addition localized to the cytosol, the Golgi apparatus & actin filaments.

Main location

 Plasma membrane (supported)

Additional location

 Golgi apparatus (approved), Actin filaments (approved), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB019322 A-431 Golgi apparatus
Plasma membrane
CAB019322 U-2 OS Golgi apparatus
Plasma membrane
Actin filaments
CAB019322 U-251 MG Golgi apparatus
Cytosol
HPA004747 A-431 Plasma membrane
Cytosol
HPA004747 U-2 OS Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 FLNB (HGNC Symbol)

Synonyms

 ABP-278, FH1, FLN1L, LRS1, TABP, TAP

Description

 Filamin B, beta (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Chromosome

 3

Cytoband

 p14.3

Chromosome location (bp)

 58008400 - 58172251

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136068 (version 83.38)

Entrez gene

 2317

UniProt

 O75369 (UniProt - Evidence at protein level)

neXtProt

 NX_O75369

Antibodypedia

 FLNB antibodies

PROTEIN BROWSER
FLNB-001
FLNB-002
FLNB-003
FLNB-004
FLNB-005
FLNB-009
FLNB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FLNB-001
ENSP00000295956
ENST00000295956
O75369 [Direct mapping]
Filamin-B
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007165 [signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030018 [Z disc]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
Show all
 2602 aa
278.2 kDa 		No 0
FLNB-002
ENSP00000420213
ENST00000490882
O75369 [Direct mapping]
Filamin-B
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003334 [keratinocyte development]
GO:0003382 [epithelial cell morphogenesis]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007165 [signal transduction]
GO:0007519 [skeletal muscle tissue development]
GO:0015629 [actin cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030018 [Z disc]
GO:0030036 [actin cytoskeleton organization]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
Show all
 2633 aa
281.6 kDa 		No 0
FLNB-003
ENSP00000351339
ENST00000358537
O75369 [Direct mapping]
Filamin-B
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007165 [signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030018 [Z disc]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
Show all
 2578 aa
275.7 kDa 		No 0
FLNB-004
ENSP00000420199
ENST00000466455
H7C5L4 [Direct mapping]
Filamin-B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
Show all
 135 aa
14.1 kDa 		No 0
FLNB-005
ENSP00000415599
ENST00000429972
O75369 [Direct mapping]
Filamin-B
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007165 [signal transduction]
GO:0015629 [actin cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030018 [Z disc]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
Show all
 2591 aa
276.9 kDa 		No 0
FLNB-009
ENSP00000418510
ENST00000493452
E7EN95 [Direct mapping]
Filamin-B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
Show all
 2409 aa
256.3 kDa 		No 0
FLNB-201
ENSP00000414532
ENST00000419752
A0A0A0MT44 [Direct mapping]
Filamin-B
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
Show all
 195 aa
20.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.