Tissue expression of ENTPD1 - Summary - The Human Protein Atlas

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ENTPD1

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ENTPD1
Gene description	Ectonucleoside triphosphate diphosphohydrolase 1
Protein class	CD markers Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (endometrium)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression mainly in trophoblastic cells and in endothelial cells. Also expressed in a subset of cells in lymphoid tissue.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images. Paired antibodies with high similarity supports the protein expression profile.
Reliability score	Supported based on 2 antibodies. HPA014067 , CAB002494
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (endometrium)

GENE INFORMATION
Gene name	ENTPD1 (HGNC Symbol)
Synonyms	ATPDase, CD39, NTPDase-1, SPG64
Description	Ectonucleoside triphosphate diphosphohydrolase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Chromosome	10
Cytoband	q24.1
Chromosome location (bp)	95711779 - 95869695
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138185 (version 83.38)
Entrez gene	953
UniProt	P49961 (UniProt - Evidence at protein level)
neXtProt	NX_P49961
Antibodypedia	ENTPD1 antibodies

PROTEIN BROWSER

ENTPD1-005	ENTPD1-008	ENTPD1-012	ENTPD1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ENTPD1-005 ENSP00000390955 ENST00000453258	P49961 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 1 Show all	Enzymes ENZYME proteins Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	517 aa 58.7 kDa	No	1
ENTPD1-008 ENSP00000360248 ENST00000371205	P49961 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 1 Show all	Enzymes ENZYME proteins Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	510 aa 58 kDa	No	1
ENTPD1-012 ENSP00000442968 ENST00000543964	P49961 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 1 Show all	Enzymes ENZYME proteins Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	402 aa 46.2 kDa	No	1
ENTPD1-015 ENSP00000360250 ENST00000371207	P49961 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 1 Show all	Enzymes ENZYME proteins Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	522 aa 59.3 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.