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Malignant tissues were generally negative. Weak nuclear and cytoplasmic staining was observed in rare cases of cervical and lung carcinoma and in malignant gliomas. Dot-like nuclear or cytoplasmic staining was found in rare cases of urothelial and testis carcinoma. Tumor stroma was distinctly positive.
Malignant tissues were negative or showed weak nuclear staining.
GENE INFORMATION
Gene name
FBLN5 (HGNC Symbol)
Synonyms
ARMD3, DANCE, EVEC, UP50
Description
Fibulin 5 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
