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DUSP15

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GENERAL INFORMATION

Gene name

 DUSP15

Gene description

 Dual specificity phosphatase 15

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & cytosol.

RNA cell category

 Cell line enhanced (REH, SH-SY5Y)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA076649
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (REH, SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & cytosol.

Main location

 Plasma membrane (approved), Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA076649 SH-SY5Y No staining    
HPA076649 U-2 OS Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 DUSP15 (HGNC Symbol)

Synonyms

 bA243J16.5, bA243J16.6, C20orf57, FLJ20645, VHY

Description

 Dual specificity phosphatase 15 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 31847637 - 31870747

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149599 (version 83.38)

Entrez gene

 128853

UniProt

 Q9H1R2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H1R2

Antibodypedia

 DUSP15 antibodies

PROTEIN BROWSER
DUSP15-001
DUSP15-002
DUSP15-004
DUSP15-005
DUSP15-006
DUSP15-007
DUSP15-009
DUSP15-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUSP15-001
ENSP00000381158
ENST00000398084
Q9H1R2 [Direct mapping]
Dual specificity protein phosphatase 15
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 132 aa
14.7 kDa 		No 0
DUSP15-002
ENSP00000341658
ENST00000339738
Q9H1R2 [Direct mapping]
Dual specificity protein phosphatase 15
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 235 aa
26.2 kDa 		No 0
DUSP15-004
ENSP00000278979
ENST00000278979
Q9H1R2 [Direct mapping]
Dual specificity protein phosphatase 15
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 295 aa
31.9 kDa 		No 0
DUSP15-005
ENSP00000419818
ENST00000486996
Q9H1R2 [Direct mapping]
Dual specificity protein phosphatase 15
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 132 aa
14.7 kDa 		No 0
DUSP15-006
ENSP00000390355
ENST00000428829
Q5QP64 [Direct mapping]
Dual-specificity protein phosphatase 15
Show all
Predicted intracellular proteins
Show all
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 76 aa
8.1 kDa 		No 0
DUSP15-007
ENSP00000365133
ENST00000375966
Q9H1R2 [Direct mapping]
Dual specificity protein phosphatase 15
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 232 aa
25.9 kDa 		No 0
DUSP15-009
ENSP00000397486
ENST00000447647
H0Y5A2 [Direct mapping]
Dual-specificity protein phosphatase 15
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 93 aa
9.8 kDa 		No 0
DUSP15-201
ENSP00000381157
ENST00000398083
Q9H1R2 [Direct mapping]
Dual specificity protein phosphatase 15
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0046330 [positive regulation of JNK cascade]
Show all
 132 aa
14.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.