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EIF5B

GENERAL INFORMATION

Gene name

 EIF5B

Gene description

 Eukaryotic translation initiation factor 5B

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA034648
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 EIF5B (HGNC Symbol)

Synonyms

 DKFZp434I036, FLJ10524, IF2, KIAA0741

Description

 Eukaryotic translation initiation factor 5B (HGNC Symbol)

Entrez gene summary

 Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 99337353 - 99401326

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158417 (version 83.38)

Entrez gene

 9669

UniProt

 O60841 (UniProt - Evidence at protein level)

neXtProt

 NX_O60841

Antibodypedia

 EIF5B antibodies

PROTEIN BROWSER
EIF5B-001
EIF5B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF5B-001
ENSP00000289371
ENST00000289371
O60841 [Direct mapping]
Eukaryotic translation initiation factor 5B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010467 [gene expression]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
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 1220 aa
138.8 kDa 		No 0
EIF5B-201
ENSP00000478914
ENST00000617677
A0A087WUT6 [Direct mapping]
Eukaryotic translation initiation factor 5B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
Show all
 1220 aa
138.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.