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PDE9A

GENERAL INFORMATION

Gene name

 PDE9A

Gene description

 Phosphodiesterase 9A

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (prostate)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a number of tissues, strong in prostate and epididymis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA011380
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDE9A

Synonyms

Description

 Phosphodiesterase 9A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 42653636 - 42775509

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160191 (version 83.38)

Entrez gene

 5152

UniProt

 O76083 (UniProt - Evidence at protein level)

neXtProt

 NX_O76083

Antibodypedia

 PDE9A antibodies

PROTEIN BROWSER
«
PDE9A-001
PDE9A-004
PDE9A-005
PDE9A-006
PDE9A-008
PDE9A-009
PDE9A-010
PDE9A-012
PDE9A-013
PDE9A-014
PDE9A-016
PDE9A-019
PDE9A-020
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDE9A-001
ENSP00000369685
ENST00000380328
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 540 aa
62.5 kDa 		No 0
PDE9A-004
ENSP00000344730
ENST00000349112
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 465 aa
54.1 kDa 		No 0
PDE9A-005
ENSP00000381280
ENST00000398224
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 466 aa
54.4 kDa 		No 0
PDE9A-006
ENSP00000381287
ENST00000398232
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 526 aa
61.2 kDa 		No 0
PDE9A-008
ENSP00000335242
ENST00000335512
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 533 aa
61.7 kDa 		No 0
PDE9A-009
ENSP00000381289
ENST00000398234
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 492 aa
57.3 kDa 		No 0
PDE9A-010
ENSP00000381291
ENST00000398236
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 507 aa
58.9 kDa 		No 0
PDE9A-012
ENSP00000328699
ENST00000328862
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 567 aa
65.7 kDa 		No 0
PDE9A-013
ENSP00000335365
ENST00000335440
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 491 aa
57.3 kDa 		No 0
PDE9A-014
ENSP00000381281
ENST00000398225
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 552 aa
64.1 kDa 		No 0
PDE9A-016
ENSP00000291539
ENST00000291539
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0019934 [cGMP-mediated signaling]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0043204 [perikaryon]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 593 aa
68.5 kDa 		No 0
PDE9A-019
ENSP00000381285
ENST00000398229
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 459 aa
53.5 kDa 		No 0
PDE9A-020
ENSP00000381283
ENST00000398227
O76083 [Direct mapping]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0032587 [ruffle membrane]
GO:0042383 [sarcolemma]
GO:0046068 [cGMP metabolic process]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 433 aa
50.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.