Expression of FLAD1 in cancer - Summary

CANCER ATLAS

Gene description

Flavin adenine dinucleotide synthetase 1

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028476	HPA028486	HPA028563

GENE INFORMATION
Gene name	FLAD1 (HGNC Symbol)
Synonyms	FAD1, PP591
Description	Flavin adenine dinucleotide synthetase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	154983338 - 154993111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160688 (version 83.38)
Entrez gene	80308
UniProt	Q8NFF5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFF5
Antibodypedia	FLAD1 antibodies

PROTEIN BROWSER

FLAD1-001	FLAD1-002	FLAD1-003	FLAD1-004	FLAD1-005	FLAD1-006	FLAD1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FLAD1-001 ENSP00000292180 ENST00000292180	Q8NFF5 [Direct mapping] FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003919 [FMN adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006747 [FAD biosynthetic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0008152 [metabolic process] GO:0044281 [small molecule metabolic process] Show all	587 aa 65.3 kDa	No	0
FLAD1-002 ENSP00000317296 ENST00000315144	Q8NFF5 [Direct mapping] FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003919 [FMN adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006747 [FAD biosynthetic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0008152 [metabolic process] GO:0044281 [small molecule metabolic process] Show all	490 aa 54.2 kDa	No	0
FLAD1-003 ENSP00000357417 ENST00000368432	Q8NFF5 [Direct mapping] FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003919 [FMN adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006747 [FAD biosynthetic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0008152 [metabolic process] GO:0044281 [small molecule metabolic process] Show all	446 aa 49.2 kDa	No	0
FLAD1-004 ENSP00000357418 ENST00000368433	Q5T196 [Direct mapping] FAD synthase; Fad1, flavin adenine dinucleotide synthetase, homolog (Yeast), isoform CRA_e Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003919 [FMN adenylyltransferase activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006747 [FAD biosynthetic process] Show all	456 aa 50.1 kDa	No	0
FLAD1-005 ENSP00000357416 ENST00000368431	Q8NFF5 [Direct mapping] FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003919 [FMN adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006747 [FAD biosynthetic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0044281 [small molecule metabolic process] Show all	294 aa 32.4 kDa	No	0
FLAD1-006 ENSP00000295530 ENST00000295530	Q5T191 [Direct mapping] FAD synthase; Fad1, flavin adenine dinucleotide synthetase, homolog (Yeast), isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 18.6 kDa	No	0
FLAD1-009 ENSP00000357413 ENST00000368428	Q5T190 [Direct mapping] FAD synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	128 aa 14.8 kDa	No	0