Tissue expression of FLAD1 - Summary - The Human Protein Atlas

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FLAD1

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FLAD1
Gene description	Flavin adenine dinucleotide synthetase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA028476 , HPA028486 , HPA028563
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	FLAD1 (HGNC Symbol)
Synonyms	FAD1, PP591
Description	Flavin adenine dinucleotide synthetase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	154983338 - 154993111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160688 (version 83.38)
Entrez gene	80308
UniProt	Q8NFF5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFF5
Antibodypedia	FLAD1 antibodies

PROTEIN BROWSER

FLAD1-001	FLAD1-002	FLAD1-003	FLAD1-004	FLAD1-005	FLAD1-006	FLAD1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FLAD1-001 ENSP00000292180 ENST00000292180	Q8NFF5 [Direct mapping] FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003919 [FMN adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006747 [FAD biosynthetic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0008152 [metabolic process] GO:0044281 [small molecule metabolic process] Show all	587 aa 65.3 kDa	No	0
FLAD1-002 ENSP00000317296 ENST00000315144	Q8NFF5 [Direct mapping] FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003919 [FMN adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006747 [FAD biosynthetic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0008152 [metabolic process] GO:0044281 [small molecule metabolic process] Show all	490 aa 54.2 kDa	No	0
FLAD1-003 ENSP00000357417 ENST00000368432	Q8NFF5 [Direct mapping] FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003919 [FMN adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006747 [FAD biosynthetic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0008152 [metabolic process] GO:0044281 [small molecule metabolic process] Show all	446 aa 49.2 kDa	No	0
FLAD1-004 ENSP00000357418 ENST00000368433	Q5T196 [Direct mapping] FAD synthase; Fad1, flavin adenine dinucleotide synthetase, homolog (Yeast), isoform CRA_e Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003919 [FMN adenylyltransferase activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006747 [FAD biosynthetic process] Show all	456 aa 50.1 kDa	No	0
FLAD1-005 ENSP00000357416 ENST00000368431	Q8NFF5 [Direct mapping] FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003919 [FMN adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006747 [FAD biosynthetic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0044281 [small molecule metabolic process] Show all	294 aa 32.4 kDa	No	0
FLAD1-006 ENSP00000295530 ENST00000295530	Q5T191 [Direct mapping] FAD synthase; Fad1, flavin adenine dinucleotide synthetase, homolog (Yeast), isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 18.6 kDa	No	0
FLAD1-009 ENSP00000357413 ENST00000368428	Q5T190 [Direct mapping] FAD synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	128 aa 14.8 kDa	No	0

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The Human Protein Atlas

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