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GFI1

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GENERAL INFORMATION

Gene name

 GFI1

Gene description

 Growth factor independent 1 transcription repressor

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-937, THP-1, HL-60)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-937, THP-1, HL-60)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GFI1 (HGNC Symbol)

Synonyms

 GFI-1, GFI1A, ZNF163

Description

 Growth factor independent 1 transcription repressor (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p22.1

Chromosome location (bp)

 92474762 - 92486876

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162676 (version 83.38)

Entrez gene

 2672

UniProt

 Q99684 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99684

Antibodypedia

 GFI1 antibodies

PROTEIN BROWSER
GFI1-001
GFI1-002
GFI1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GFI1-001
ENSP00000359357
ENST00000370332
Q99684 [Direct mapping]
Zinc finger protein Gfi-1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Show all
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007638 [mechanosensory behavior]
GO:0008270 [zinc ion binding]
GO:0009996 [negative regulation of cell fate specification]
GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity]
GO:0010957 [negative regulation of vitamin D biosynthetic process]
GO:0010977 [negative regulation of neuron projection development]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0017053 [transcriptional repressor complex]
GO:0030099 [myeloid cell differentiation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0042491 [auditory receptor cell differentiation]
GO:0042660 [positive regulation of cell fate specification]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045165 [cell fate commitment]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0070105 [positive regulation of interleukin-6-mediated signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
Show all
 422 aa
45.3 kDa 		No 0
GFI1-002
ENSP00000294702
ENST00000294702
Q99684 [Direct mapping]
Zinc finger protein Gfi-1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Show all
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity]
GO:0010957 [negative regulation of vitamin D biosynthetic process]
GO:0010977 [negative regulation of neuron projection development]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0017053 [transcriptional repressor complex]
GO:0030099 [myeloid cell differentiation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0070105 [positive regulation of interleukin-6-mediated signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
Show all
 422 aa
45.3 kDa 		No 0
GFI1-201
ENSP00000399719
ENST00000427103
Q99684 [Direct mapping]
Zinc finger protein Gfi-1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Show all
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity]
GO:0010957 [negative regulation of vitamin D biosynthetic process]
GO:0010977 [negative regulation of neuron projection development]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0017053 [transcriptional repressor complex]
GO:0030099 [myeloid cell differentiation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0070105 [positive regulation of interleukin-6-mediated signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
Show all
 422 aa
45.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.