Expression of SLC30A7 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 30 (zinc transporter), member 7

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018034

GENE INFORMATION
Gene name	SLC30A7 (HGNC Symbol)
Synonyms	ZNT7, ZnTL2
Description	Solute carrier family 30 (zinc transporter), member 7 (HGNC Symbol)
Entrez gene summary	Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]
Chromosome	1
Cytoband	p21.2
Chromosome location (bp)	100896076 - 100981753
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162695 (version 83.38)
Entrez gene	148867
UniProt	Q8NEW0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NEW0
Antibodypedia	SLC30A7 antibodies

PROTEIN BROWSER

SLC30A7-001	SLC30A7-002	SLC30A7-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC30A7-001 ENSP00000359130 ENST00000370112	Q8NEW0 [Direct mapping] Zinc transporter 7 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006812 [cation transport] GO:0006829 [zinc II ion transport] GO:0008324 [cation transmembrane transporter activity] GO:0010043 [response to zinc ion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0031982 [vesicle] GO:0032119 [sequestering of zinc ion] GO:0044267 [cellular protein metabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0055085 [transmembrane transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0070062 [extracellular exosome] GO:0071577 [zinc II ion transmembrane transport] Show all	376 aa 41.6 kDa	No	7
SLC30A7-002 ENSP00000350278 ENST00000357650	Q8NEW0 [Direct mapping] Zinc transporter 7 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0010043 [response to zinc ion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0070062 [extracellular exosome] GO:0071577 [zinc II ion transmembrane transport] Show all	376 aa 41.6 kDa	No	7
SLC30A7-003 ENSP00000359129 ENST00000370111	H0Y362 [Direct mapping] Zinc transporter 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	87 aa 9.8 kDa	No	0