Expression of ARHGAP25 in cancer - Summary

CANCER ATLAS

Gene description

Rho GTPase activating protein 25

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035346	HPA061395

GENE INFORMATION
Gene name	ARHGAP25 (HGNC Symbol)
Synonyms	KIAA0053
Description	Rho GTPase activating protein 25 (HGNC Symbol)
Entrez gene summary	ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	68679601 - 68826833
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163219 (version 83.38)
Entrez gene	9938
UniProt	P42331 (UniProt - Evidence at protein level)
neXtProt	NX_P42331
Antibodypedia	ARHGAP25 antibodies

PROTEIN BROWSER

ARHGAP25-001	ARHGAP25-002	ARHGAP25-006	ARHGAP25-008	ARHGAP25-011	ARHGAP25-014	ARHGAP25-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP25-001 ENSP00000386911 ENST00000409202	P42331 [Direct mapping] Rho GTPase-activating protein 25 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	646 aa 73.5 kDa	No	0
ARHGAP25-002 ENSP00000386863 ENST00000409030	P42331 [Direct mapping] Rho GTPase-activating protein 25 V9HWC8 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 308; Rho GTPase activating protein 25, isoform CRA_b Show all	Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	638 aa 72.4 kDa	No	0
ARHGAP25-006 ENSP00000386241 ENST00000409220	P42331 [Direct mapping] Rho GTPase-activating protein 25 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	639 aa 72.5 kDa	No	0
ARHGAP25-008 ENSP00000420583 ENST00000467265	P42331 [Direct mapping] Rho GTPase-activating protein 25 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	606 aa 69 kDa	No	0
ARHGAP25-011 ENSP00000417139 ENST00000497079	P42331 [Direct mapping] Rho GTPase-activating protein 25 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	458 aa 51.8 kDa	No	0
ARHGAP25-014 ENSP00000417818 ENST00000497259	H7C4P1 [Direct mapping] Rho GTPase-activating protein 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	505 aa 56.9 kDa	No	0
ARHGAP25-015 ENSP00000417467 ENST00000479844	C9JB56 [Direct mapping] Rho GTPase-activating protein 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	339 aa 38.2 kDa	No	0