Tissue expression of MAPRE2 - Summary - The Human Protein Atlas

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MAPRE2

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MAPRE2
Gene description	Microtubule-associated protein, RP/EB family, member 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, most abundant in the CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA016738 , HPA016739
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MAPRE2 (HGNC Symbol)
Synonyms	EB1, EB2, RP1
Description	Microtubule-associated protein, RP/EB family, member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Chromosome	18
Cytoband
Chromosome location (bp)	34976928 - 35143470
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166974 (version 83.38)
Entrez gene	10982
UniProt	Q15555 (UniProt - Evidence at protein level)
neXtProt	NX_Q15555
Antibodypedia	MAPRE2 antibodies

PROTEIN BROWSER

MAPRE2-001	MAPRE2-002	MAPRE2-003	MAPRE2-004	MAPRE2-005	MAPRE2-006	MAPRE2-008	MAPRE2-010	MAPRE2-012	MAPRE2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAPRE2-001 ENSP00000300249 ENST00000300249	Q15555 [Direct mapping] Microtubule-associated protein RP/EB family member 2 A0A024RC33 [Target identity:100%; Query identity:100%] Microtubule-associated protein, RP/EB family, member 2, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0007165 [signal transduction] GO:0008017 [microtubule binding] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0035371 [microtubule plus-end] GO:0051301 [cell division] Show all	327 aa 37 kDa	No	0
MAPRE2-002 ENSP00000407723 ENST00000436190	Q15555 [Direct mapping] Microtubule-associated protein RP/EB family member 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0007165 [signal transduction] GO:0008017 [microtubule binding] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0051301 [cell division] Show all	315 aa 35.7 kDa	No	0
MAPRE2-003 ENSP00000446343 ENST00000538170	Q15555 [Direct mapping] Microtubule-associated protein RP/EB family member 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0007165 [signal transduction] GO:0008017 [microtubule binding] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0051301 [cell division] Show all	274 aa 30.7 kDa	No	0
MAPRE2-004 ENSP00000468588 ENST00000588910	Q15555 [Direct mapping] Microtubule-associated protein RP/EB family member 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0007165 [signal transduction] GO:0008017 [microtubule binding] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0051301 [cell division] Show all	259 aa 29.1 kDa	No	0
MAPRE2-005 ENSP00000464921 ENST00000589699	Q15555 [Direct mapping] Microtubule-associated protein RP/EB family member 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0007165 [signal transduction] GO:0008017 [microtubule binding] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0051301 [cell division] Show all	284 aa 32.2 kDa	No	0
MAPRE2-006 ENSP00000468216 ENST00000591734	K7ERD8 [Direct mapping] Microtubule-associated protein RP/EB family member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008017 [microtubule binding] Show all	194 aa 21.6 kDa	No	0
MAPRE2-008 ENSP00000466871 ENST00000587359	K7ENB3 [Direct mapping] Microtubule-associated protein RP/EB family member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008017 [microtubule binding] Show all	78 aa 9 kDa	No	0
MAPRE2-010 ENSP00000465939 ENST00000589180	K7EL66 [Direct mapping] Microtubule-associated protein RP/EB family member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008017 [microtubule binding] Show all	134 aa 15 kDa	No	0
MAPRE2-012 ENSP00000468904 ENST00000588349	M0QX52 [Direct mapping] Microtubule-associated protein RP/EB family member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008017 [microtubule binding] Show all	127 aa 14.9 kDa	No	0
MAPRE2-201 ENSP00000396074 ENST00000413393	Q15555 [Direct mapping] Microtubule-associated protein RP/EB family member 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007067 [mitotic nuclear division] GO:0007165 [signal transduction] GO:0008017 [microtubule binding] GO:0008283 [cell proliferation] GO:0015630 [microtubule cytoskeleton] GO:0051301 [cell division] Show all	284 aa 32.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.