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IRF2

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GENERAL INFORMATION

Gene name

 IRF2

Gene description

 Interferon regulatory factor 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Additional location

 In addition localized to the Cytosol (validated)

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
HPA030813 , CAB032306 , HPA057327
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (validated)

Additional location

 Cytosol (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA030813 A-431 Nucleoplasm
Focal adhesion sites
HPA030813 U-2 OS Nucleoplasm
HPA030813 U-251 MG Nucleoplasm
CAB032306 A-431 Nucleoplasm
Cytosol
CAB032306 U-2 OS Nucleoplasm
Cytosol
CAB032306 U-251 MG Nucleoplasm
Cytosol
HPA057327 A-431 Nucleoplasm
Cytosol
HPA057327 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 IRF2

Synonyms

Description

 Interferon regulatory factor 2 (HGNC Symbol)

Entrez gene summary

 IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q35.1

Chromosome location (bp)

 184387713 - 184474580

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168310 (version 83.38)

Entrez gene

 3660

UniProt

 P14316 (UniProt - Evidence at protein level)

neXtProt

 NX_P14316

Antibodypedia

 IRF2 antibodies

PROTEIN BROWSER
IRF2-001
IRF2-004
IRF2-005
IRF2-007
IRF2-009
IRF2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IRF2-001
ENSP00000377218
ENST00000393593
P14316 [Direct mapping]
Interferon regulatory factor 2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000975 [regulatory region DNA binding]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
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 349 aa
39.4 kDa 		No 0
IRF2-004
ENSP00000422860
ENST00000506230
D6R9N5 [Direct mapping]
Interferon regulatory factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
Show all
 137 aa
16.2 kDa 		No 0
IRF2-005
ENSP00000427204
ENST00000507523
K4DIA5 [Direct mapping]
Interferon regulatory factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
Show all
 176 aa
20.3 kDa 		No 0
IRF2-007
ENSP00000424552
ENST00000510814
D6RB08 [Direct mapping]
Interferon regulatory factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
Show all
 161 aa
18.7 kDa 		No 0
IRF2-009
ENSP00000421927
ENST00000505067
K4DIA4 [Direct mapping]
Interferon regulatory factor 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
Show all
 196 aa
21.8 kDa 		No 0
IRF2-010
ENSP00000423074
ENST00000502750
H0Y956 [Direct mapping]
Interferon regulatory factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008283 [cell proliferation]
Show all
 113 aa
12.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.