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Moderate to strong cytoplasmic and/or nucleolar immunoreactivity was observed in most malignant melanomas, breast, prostate and colorectal cancers as well as cases of urothelial, liver and pancreatic cancers. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
RSPO1 (HGNC Symbol)
Synonyms
FLJ40906, RSPONDIN
Description
R-spondin 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]