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Rare case of carcinoid and urothelial cancer displayed moderate cytoplasmic positivity. Additional nuclear and/or membranous staining was observed in a case of melanoma and liver cancer. Remaining cancer tissues were weakly stained or negative.
Several cases of pancreatic, breast, lung, stomach and liver cancers showed weak to moderate cytoplasmic positivity. Remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
DAB1
Synonyms
Description
Dab, reelin signal transducer, homolog 1 (Drosophila) (HGNC Symbol)
Entrez gene summary
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]