Cell atlas - IQCK - The Human Protein Atlas

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IQCK

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear speckles

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IQCK
Gene description	IQ motif containing K
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at transcript level
Main location	Localized to the Nuclear speckles (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048786
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles. In addition localized to the cytosol.

Main location

Nuclear speckles (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048786	A-431	Nuclear speckles
	HPA048786	A549	Nuclear speckles
	HPA048786	A549	Cytosol
	HPA048786	U-2 OS	Nuclear speckles
	HPA048786	U-2 OS	Cytosol

GENE INFORMATION
Gene name	IQCK (HGNC Symbol)
Synonyms	FLJ36575, MGC35048
Description	IQ motif containing K (HGNC Symbol)
Entrez gene summary	This gene belongs to the IQ motif-containing family of proteins. The IQ motif serves as a binding site for different EF-hand proteins such as calmodulin. This gene was identified as a potential candidate gene for obsessive-compulsive disorder in a genome-wide association study. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	19716456 - 19858467
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000174628 (version 83.38)
Entrez gene	124152
UniProt	Q8N0W5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N0W5
Antibodypedia	IQCK antibodies

PROTEIN BROWSER

IQCK-001	IQCK-007	IQCK-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IQCK-001 ENSP00000324901 ENST00000320394	Q8N0W5 [Direct mapping] IQ domain-containing protein K Show all	Predicted intracellular proteins Show all		287 aa 33.3 kDa	No	0
IQCK-007 ENSP00000458669 ENST00000564186	I3L193 [Direct mapping] IQ domain-containing protein K Show all	Predicted intracellular proteins Show all		282 aa 32.8 kDa	No	0
IQCK-013 ENSP00000455504 ENST00000568061	H3BPX0 [Direct mapping] IQ domain-containing protein K Show all	Predicted intracellular proteins Show all		58 aa 6.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.