Fields »
ABOUT
HELP
BLOG
SLC22A1

GENERAL INFORMATION

Gene name

 SLC22A1

Gene description

 Solute carrier family 22 (organic cation transporter), member 1

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA029846
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Cervix, uterine

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 SLC22A1 (HGNC Symbol)

Synonyms

 OCT1

Description

 Solute carrier family 22 (organic cation transporter), member 1 (HGNC Symbol)

Entrez gene summary

 Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q25.3

Chromosome location (bp)

 160121789 - 160158718

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175003 (version 83.38)

Entrez gene

 6580

UniProt

 O15245 (UniProt - Evidence at protein level)

neXtProt

 NX_O15245

Antibodypedia

 SLC22A1 antibodies

PROTEIN BROWSER
SLC22A1-001
SLC22A1-005
SLC22A1-006
SLC22A1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC22A1-001
ENSP00000355930
ENST00000366963
O15245 [Direct mapping]
Solute carrier family 22 member 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005277 [acetylcholine transmembrane transporter activity]
GO:0005329 [dopamine transmembrane transporter activity]
GO:0005333 [norepinephrine transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0006836 [neurotransmitter transport]
GO:0006855 [drug transmembrane transport]
GO:0008504 [monoamine transmembrane transporter activity]
GO:0008513 [secondary active organic cation transmembrane transporter activity]
GO:0010248 [establishment or maintenance of transmembrane electrochemical gradient]
GO:0015075 [ion transmembrane transporter activity]
GO:0015101 [organic cation transmembrane transporter activity]
GO:0015651 [quaternary ammonium group transmembrane transporter activity]
GO:0015695 [organic cation transport]
GO:0015697 [quaternary ammonium group transport]
GO:0015844 [monoamine transport]
GO:0015872 [dopamine transport]
GO:0015874 [norepinephrine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0048241 [epinephrine transport]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
GO:1901374 [acetate ester transport]
Show all
 554 aa
61.2 kDa 		No >9
SLC22A1-005
ENSP00000440105
ENST00000540443
F5GY86 [Direct mapping]
Solute carrier family 22 member 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Show all
 48 aa
5.4 kDa 		No 0
SLC22A1-006
ENSP00000318103
ENST00000324965
O15245 [Direct mapping]
Solute carrier family 22 member 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005277 [acetylcholine transmembrane transporter activity]
GO:0005329 [dopamine transmembrane transporter activity]
GO:0005333 [norepinephrine transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006836 [neurotransmitter transport]
GO:0006855 [drug transmembrane transport]
GO:0008513 [secondary active organic cation transmembrane transporter activity]
GO:0015075 [ion transmembrane transporter activity]
GO:0015101 [organic cation transmembrane transporter activity]
GO:0015651 [quaternary ammonium group transmembrane transporter activity]
GO:0015695 [organic cation transport]
GO:0015697 [quaternary ammonium group transport]
GO:0015872 [dopamine transport]
GO:0015874 [norepinephrine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
Show all
 506 aa
56.1 kDa 		No >9
SLC22A1-007
ENSP00000409557
ENST00000457470
O15245 [Direct mapping]
Solute carrier family 22 member 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005277 [acetylcholine transmembrane transporter activity]
GO:0005329 [dopamine transmembrane transporter activity]
GO:0005333 [norepinephrine transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006836 [neurotransmitter transport]
GO:0006855 [drug transmembrane transport]
GO:0008513 [secondary active organic cation transmembrane transporter activity]
GO:0015075 [ion transmembrane transporter activity]
GO:0015101 [organic cation transmembrane transporter activity]
GO:0015651 [quaternary ammonium group transmembrane transporter activity]
GO:0015695 [organic cation transport]
GO:0015697 [quaternary ammonium group transport]
GO:0015872 [dopamine transport]
GO:0015874 [norepinephrine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
Show all
 483 aa
53.6 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.