Expression of PFAS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Phosphoribosylformylglycinamidine synthase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA022140	HPA022886

GENE INFORMATION
Gene name	PFAS (HGNC Symbol)
Synonyms	FGARAT, KIAA0361, PURL
Description	Phosphoribosylformylglycinamidine synthase (HGNC Symbol)
Entrez gene summary	Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	8247618 - 8270491
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178921 (version 83.38)
Entrez gene	5198
UniProt	O15067 (UniProt - Evidence at protein level)
neXtProt	NX_O15067
Antibodypedia	PFAS antibodies

PROTEIN BROWSER

PFAS-001	PFAS-003	PFAS-004	PFAS-005	PFAS-007	PFAS-008	PFAS-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PFAS-001 ENSP00000313490 ENST00000314666	O15067 [Direct mapping] Phosphoribosylformylglycinamidine synthase Show all	Enzymes ENZYME proteins Ligase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004642 [phosphoribosylformylglycinamidine synthase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006164 [purine nucleotide biosynthetic process] GO:0006189 ['de novo' IMP biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0009156 [ribonucleoside monophosphate biosynthetic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0042493 [response to drug] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	1338 aa 144.7 kDa	No	0
PFAS-003 ENSP00000462874 ENST00000583059	J3KT98 [Direct mapping] Phosphoribosylformylglycinamidine synthase Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006164 [purine nucleotide biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0009156 [ribonucleoside monophosphate biosynthetic process] Show all	117 aa 12.2 kDa	No	0
PFAS-004 ENSP00000443244 ENST00000546020	H0YGH1 [Direct mapping] Phosphoribosylformylglycinamidine synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006164 [purine nucleotide biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0009156 [ribonucleoside monophosphate biosynthetic process] Show all	385 aa 41.2 kDa	No	0
PFAS-005 ENSP00000463362 ENST00000585183	J3QL39 [Direct mapping] Phosphoribosylformylglycinamidine synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006164 [purine nucleotide biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0009156 [ribonucleoside monophosphate biosynthetic process] Show all	88 aa 9.8 kDa	No	0
PFAS-007 ENSP00000464689 ENST00000584044	J3QSH6 [Direct mapping] Phosphoribosylformylglycinamidine synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006164 [purine nucleotide biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0009156 [ribonucleoside monophosphate biosynthetic process] Show all	135 aa 14.9 kDa	No	0
PFAS-008 ENSP00000463045 ENST00000581242	J3KTL4 [Direct mapping] Phosphoribosylformylglycinamidine synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006164 [purine nucleotide biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0009156 [ribonucleoside monophosphate biosynthetic process] Show all	103 aa 11.4 kDa	No	0
PFAS-201 ENSP00000487260 ENST00000625942	J3QSG0 [Direct mapping] Phosphoribosylformylglycinamidine synthase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006164 [purine nucleotide biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0009156 [ribonucleoside monophosphate biosynthetic process] Show all	131 aa 14.6 kDa	No	0