Expression of FUCA1 in cancer - Summary

CANCER ATLAS

Gene description

Fucosidase, alpha-L- 1, tissue

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA046542	HPA056371

GENE INFORMATION
Gene name	FUCA1
Synonyms
Description	Fucosidase, alpha-L- 1, tissue (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009]
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	23845077 - 23868294
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179163 (version 83.38)
Entrez gene	2517
UniProt	P04066 (UniProt - Evidence at protein level)
neXtProt	NX_P04066
Antibodypedia	FUCA1 antibodies

PROTEIN BROWSER

FUCA1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FUCA1-001 ENSP00000363603 ENST00000374479	P04066 [Direct mapping] Tissue alpha-L-fucosidase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004560 [alpha-L-fucosidase activity] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005975 [carbohydrate metabolic process] GO:0006004 [fucose metabolic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0015928 [fucosidase activity] GO:0016139 [glycoside catabolic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0043202 [lysosomal lumen] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	466 aa 53.7 kDa	Yes	0