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FUCA1

GENERAL INFORMATION

Gene name

 FUCA1

Gene description

 Fucosidase, alpha-L- 1, tissue

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including lysosomes in the gastrointestinal tract and lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA046542 , HPA056371
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FUCA1

Synonyms

Description

 Fucosidase, alpha-L- 1, tissue (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 23845077 - 23868294

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179163 (version 83.38)

Entrez gene

 2517

UniProt

 P04066 (UniProt - Evidence at protein level)

neXtProt

 NX_P04066

Antibodypedia

 FUCA1 antibodies

PROTEIN BROWSER
FUCA1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FUCA1-001
ENSP00000363603
ENST00000374479
P04066 [Direct mapping]
Tissue alpha-L-fucosidase
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004560 [alpha-L-fucosidase activity]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006004 [fucose metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0015928 [fucosidase activity]
GO:0016139 [glycoside catabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030246 [carbohydrate binding]
GO:0043202 [lysosomal lumen]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
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 466 aa
53.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.