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SFTPA2

CANCER ATLAS

Gene description

 Surfactant protein A2

Protein class

 Disease related genes, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA042638
HPA045752
HPA049368
CAB002439

GENE INFORMATION

Gene name

 SFTPA2 (HGNC Symbol)

Synonyms

 COLEC5, SP-A2

Description

 Surfactant protein A2 (HGNC Symbol)

Entrez gene summary

 This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009]

Chromosome

 10

Cytoband

 q22.3

Chromosome location (bp)

 79555852 - 79560397

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185303 (version 83.38)

Entrez gene

 729238

UniProt

 Q8IWL1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IWL1

Antibodypedia

 SFTPA2 antibodies

PROTEIN BROWSER
SFTPA2-001
SFTPA2-003
SFTPA2-006
SFTPA2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SFTPA2-001
ENSP00000361400
ENST00000372325
Q8IWL1 [Direct mapping]
Pulmonary surfactant-associated protein A2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0007585 [respiratory gaseous exchange]
GO:0030246 [carbohydrate binding]
GO:0042599 [lamellar body]
GO:0044267 [cellular protein metabolic process]
GO:0045334 [clathrin-coated endocytic vesicle]
Show all
 248 aa
26.2 kDa 		Yes 0
SFTPA2-003
ENSP00000397375
ENST00000417041
X6REF7 [Direct mapping]
Pulmonary surfactant-associated protein A2
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
 158 aa
15.9 kDa 		Yes 0
SFTPA2-006
ENSP00000473275
ENST00000492049
R4GMN3 [Direct mapping]
Pulmonary surfactant-associated protein A2
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
 98 aa
9.4 kDa 		Yes 0
SFTPA2-201
ENSP00000361402
ENST00000372327
Q8IWL1 [Direct mapping]
Pulmonary surfactant-associated protein A2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0007585 [respiratory gaseous exchange]
GO:0030246 [carbohydrate binding]
GO:0042599 [lamellar body]
GO:0044267 [cellular protein metabolic process]
GO:0045334 [clathrin-coated endocytic vesicle]
Show all
 248 aa
26.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.