Tissue expression of STAC3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	STAC3
Gene description	SH3 and cysteine rich domain 3
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (skeletal muscle)
GTEx:	Tissue enriched (skeletal muscle)
FANTOM5:	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION
Gene name	STAC3 (HGNC Symbol)
Synonyms	MGC2793
Description	SH3 and cysteine rich domain 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a component of the excitation-contraction coupling machinery of muscles. This protein is a member of the Stac gene family and contains an N-terminal cysteine-rich domain and two SH3 domains. Mutations in this gene are a cause of Native American myopathy. [provided by RefSeq, Nov 2013]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	57243453 - 57251193
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185482 (version 83.38)
Entrez gene	246329
UniProt	Q96MF2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96MF2
Antibodypedia	STAC3 antibodies

PROTEIN BROWSER

STAC3-001	STAC3-003	STAC3-004	STAC3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STAC3-001 ENSP00000329200 ENST00000332782	Q96MF2 [Direct mapping] SH3 and cysteine-rich domain-containing protein 3 A0A024RB38 [Target identity:100%; Query identity:100%] SH3 and cysteine rich domain 3, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007274 [neuromuscular synaptic transmission] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0046872 [metal ion binding] GO:0048741 [skeletal muscle fiber development] Show all	364 aa 41.5 kDa	No	0
STAC3-003 ENSP00000452068 ENST00000554578	Q96MF2 [Direct mapping] SH3 and cysteine-rich domain-containing protein 3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007274 [neuromuscular synaptic transmission] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0046872 [metal ion binding] Show all	325 aa 37.1 kDa	No	0
STAC3-004 ENSP00000441515 ENST00000546246	Q96MF2 [Direct mapping] SH3 and cysteine-rich domain-containing protein 3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007274 [neuromuscular synaptic transmission] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0046872 [metal ion binding] Show all	178 aa 20.3 kDa	No	0
STAC3-005 ENSP00000452299 ENST00000553489	G3V5D4 [Direct mapping] SH3 and cysteine-rich domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0035556 [intracellular signal transduction] Show all	168 aa 19.3 kDa	No	0