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Hepatocellular carcinomas along with isolated cases of urothelial cancers and follicular adenocarcinoma of thyroid showed moderate to strong cytoplasmic positivity. A single case each of breast, ovarian, cervical, head and neck and testicular cancer displayed moderate nucleolar staining. Remaining cancers were negative.
GENE INFORMATION
Gene name
CYP4F3 (HGNC Symbol)
Synonyms
CYP4F, LTB4H
Description
Cytochrome P450, family 4, subfamily F, polypeptide 3 (HGNC Symbol)
Entrez gene summary
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]