Tissue expression of PRB3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PRB3
Gene description	Proline-rich protein BstNI subfamily 3
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (salivary gland)
GTEx:	Tissue enhanced (testis, salivary gland)
FANTOM5:	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION
Gene name	PRB3 (HGNC Symbol)
Synonyms	PRG
Description	Proline-rich protein BstNI subfamily 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the ""Long"" allele. The protein isoforms encoded by this gene are recognized as the ""first line of oral defense"" against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	11265924 - 11269805
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197870 (version 83.38)
Entrez gene	5544
UniProt	Q04118 (UniProt - Evidence at protein level)
neXtProt	NX_Q04118
Antibodypedia	PRB3 antibodies

PROTEIN BROWSER

PRB3-001	PRB3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRB3-001 ENSP00000442626 ENST00000538488	F5H7C1 [Direct mapping] Basic salivary proline-rich protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		351 aa 35.1 kDa	Yes	0
PRB3-201 ENSP00000371264 ENST00000381842	Q04118 [Direct mapping] Basic salivary proline-rich protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0008150 [biological_process] GO:0050829 [defense response to Gram-negative bacterium] Show all	309 aa 31 kDa	Yes	0