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Prostate cancers displayed strong cytoplasmic positivity. Several cases of thyroid and renal cancers along with a few cases of malignant melanomas, cervical, endometrial, lung and pancreatic cancers displayed moderate to strong cytoplasmic immunoreactivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
PAX9
Synonyms
Description
Paired box 9 (HGNC Symbol)
Entrez gene summary
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3. [provided by RefSeq, Sep 2015]