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Moderate to strong cytoplasmic staining in gliomas and renal carcinomas. Weak to moderate staining in several cases of lymphomas, melanomas, adenocarcinomas of breast, endometrial, urothelial and pancreatic cancers. Remaining cancer cells were mainly negative.
GENE INFORMATION
Gene name
POU3F3 (HGNC Symbol)
Synonyms
BRN1, OTF8
Description
POU class 3 homeobox 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015]