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A few testicular, endometrial, renal, pancreatic, liver, skin and occasional urothelial cancers exhibited weak to moderate cytoplasmic and occasional membranous staining. Remaining normal tissues were negative.
GENE INFORMATION
Gene name
FBXO16 (HGNC Symbol)
Synonyms
FBX16
Description
F-box protein 16 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
